The role of molecular structure in determining biological activity is shown. The correlation of the structure of sulfanilamide with that of a vitamin essential for bacterial growth leads to a more general investigation of the biochemical nature of growth. Paper chromatography is used to separate some of the material found in chromosomes. It is proposed that compounds similar to those found in chromosomes may stop cell division and thus be useful in controlling cancer. The effect and mechanism of one such compound, 5-fluorouracil, are studied using time-lapse photography and radioactive labeling.
Science Consultant: Dr. Donald E. Rounds, Pasadena Foundation for Medical Research, Pasadena, California.
Wardâs Volume 19, CHEM Study #4181, 23 minutes. In color, 1989.